Other rat species

In roof rats (Rattus rattus) the VKORC1 sequence variant Trp59Arg presumably confers some degree of resistance. However, earlier breeding experiments with warfarin-resistant roof rats indicated considerable instability in the resistance trait and suggested a multifactorial basis for the resistance. Warfarin-resistant Rattus losea in southern China possessed an Arg58Gly VKORC1-mutation, which was absent in susceptible individuals, and some warfarin-resistant Rattus flavipectus carried the Tyr139Cys SNP.